Abstract
Publisher Summary This chapter discusses molecular events in measles virus infection of the central nervous system (CNS). The combined information on expression of measles virus RNA and proteins in human subacute sclerosing panencephalitis (SSPE) and measles inclusion body encephalitis (MIBE) brain tissue, in experimental animals, and in cell cultures helps in understanding events resulting in persistent virus infection in the CNS. Host factors, immune system interactions, and viral gene mutations might all participate at various stages in the process. There is strong evidence that restricted expression of measles RNA and proteins occurs within the CNS. Studies of animal models support the idea that the restriction is a function of the host environment, which sets the stage for initiation of persistent infection. It is not clear whether the mutations encountered in viral genes from SSPE tissue are essential for maintaining the persistent infection or are by-products of prolonged survival of genes nonessential for virus replication and cell-to-cell spread.
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