Abstract

The terms initiation, promotion and progression originated largely from studies on chemical carcinogenesis in mouse skin (Boutwell 1974), but the general applicability of these concepts to tumorigenesis in other animal systems and to humans is now recognized (Hecker et al. 1982). This review outlines the recent advances made in our understanding of the molecular genetic events associated with each step of tumor development. The conclusions reached are by necessity over-simplistic and in some cases highly speculative, but may serve to focus attention on hypotheses which have become amenable to experimental test.

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