Abstract

Different isdates of hepatitis C virus (HCV) show nuclectide genomic sequence variability distributed throughout the genome. The effect of this variability on the seroIogicaJ diagncs among the 16 different lb sequences 16116(1K%) reacted with all antigens except for the NS5 antigen ( 11116); among the 12 different 2 sequences 9112 (75%) reacted with all antigens (l@Z)%l exceot for the NS5 antieen (lli121: smo& the 18 different 3a”seqoe among the 5 different 4 sequences tested. 415 (80%) reacted with all antigens exceot for the NS5 antieen (415): among the j different 5 sequences testI among the type 6 squence tested, li l( 100%) reacted with all antigens exce@ for the NS5 antigen (01 I). Conclusions: I) Whatever a differeq~.reactivity was found in the antigen among the different HCV isolates. none of the 73 ditTerent isdates from genotype 1 to 6 are non reactive with the four commercial screening assays. 2) The reactivity of the NS5 antigen is lower than those of the others antigens 3) These results bring confident for the use of only one test for the screening of HCV patients as it has been re~~mmanded by the last French consensus conference

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