Abstract
BackgroundStreptococcus pneumoniae (S. pneumoniae) is one of the most common pathogens which can cause morbidity and mortality in pediatric infections worldwide. This study aimed to describe the phenotypic and molecular characteristics of community-acquired pneumonia (CAP)-causing S. pneumoniae recovered from children in Western China.MethodsWe retrospectively enrolled pediatric patients younger than 5 years diagnosed with CAP. All 419 S. pneumoniae isolates were tested for antibiotic susceptibility, serotypes, virulence genes, resistance genes, and sequence types. The potential relationships between molecular characteristics were tested by correspondence analysis.ResultsMost of S. pneumoniae isolates were resistant to erythromycin, tetracycline, clindamycin and trimethoprim-sulfamethoxazole, with 93.8% isolates classified as multidrug resistant. The dominant STs were ST271 (30.8%) and ST320 (12.2%), while the prevailing serotypes were 19F (46.8%), 6B (11.5%), 23F (9.5%) and 19A (9.3%). The coverage rates of PCV-7 and PCV-13 were 73.03% and 86.16%, while the coverage rates of PCV13 among children aged < 1 year and 1–2 years were high in 93.18% and 93.62%. We also observed that CC271 expressed more of mef (A/E), lytA, rlrA and sipA than non-CC271 isolates. Moreover, there were strong corresponding relationships between molecular characteristics.ConclusionsThe high coverage rate of PCV13 suggests the necessity of introducing the PCV13 vaccine in Western China. Our findings underscore the value of monitoring multiple molecular characteristics to provide new guidance for developing future pneumococcal vaccines.
Highlights
Community-acquired pneumonia (CAP) is a common childhood disease around the world
According to the World Health Organization (WHO), there are more than 900,000 deaths per year in children under than 5 years who have suffered from community-acquired pneumonia (CAP) [1]
After introduction of PCV13 into the national immunization program in the USA, there was a 21% reduction in hospital admissions for allcause CAP in children aged < 2 years, suggesting a positive impact of Pneumococcal conjugate vaccines (PCVs) immunization on CAP in children [5], especially for those caused by unique PCV13 serotypes of pneumococcal isolates which was not covered within PCV7, which were further decreased across each age group [3]
Summary
Community-acquired pneumonia (CAP) is a common childhood disease around the world. PCV7 vaccination was associated with a 19% and 33.1% reduction in the rate of CAP in children aged < 5 years and aged < 2 years, respectively, in the UK. After introduction of PCV13 into the national immunization program in the USA, there was a 21% reduction in hospital admissions for allcause CAP in children aged < 2 years, suggesting a positive impact of PCV immunization on CAP in children [5], especially for those caused by unique PCV13 serotypes of pneumococcal isolates which was not covered within PCV7, which were further decreased across each age group [3]. This study aimed to describe the phenotypic and molecular characteristics of community-acquired pneumonia (CAP)-causing S. pneumoniae recovered from children in Western China
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