Abstract
In this study, we report the phylogenetic relationship of RABV circulating in Russia. A total of 81 new isolates obtained from different regions of Russia in 2008 - 2016 were partially sequenced. Evolutionary analysis based on 100 representative sequences of rabies virus N-gene fragments (1110 nt) with sample time span ranging from 1977 to 2016 was made by the Bayesian coalescent analysis. Temporal estimates for major evolutionary events were done. The division of steppe rabies virus group C to discrete subgroups was revealed. According to our data, this most widespread in the Russian Federation group emerged in the beginning of the 1940th. The presence of steppe rabies virus was detected in the Far East (Primorsky Krai). The most likely cause of this event is anthropogenic introduction.. For the first time, representatives of arctic rabies subgroup A2 were isolated in the north of European Russia and FranzJosef Land. Evolutionary analysis suggested relatively recent emergence of all rabies virus groups currently circulating in the territory of the Russian Federation.
Highlights
In this study, we report the phylogenetic relationship of RABV circulating in Russia
Evolutionary analysis based on 100 representative sequences of rabies virus N-gene fragments (1110 nt) with sample time span ranging from 1977 to 2016 was made by the Bayesian coalescent analysis
The presence of steppe rabies virus was detected in the Far East (Primorsky Krai)
Summary
Молекулярная эпидемиология вируса бешенства на территории Российской Федерации1 Molecular Epidemiology of Rabies Virus in the Territory of the Russian Federation A.A. Deviatkin1 – 3 (andreideviatkin@gmail.com), A.N. Lukashev2 (alexander_lukashev@hotmail.com), E.M. Poleshchuk4 (e-poleschuk@yandex.ru), V.G. Dedkov1, 3 (vgdedkov@yandex.ru), S.E. Tkachev6 (tkachev@niboch.nsc.ru), G.N.Sidorov4, 7 (g.n.sidorov@ompgu.ru), I.V.Galkina5 (galkina333@mail.ru), M.Yu. Shchelkanov5 (adorob@mail.ru), G.G. Karganova2 (karganova@bk.ru), M.V. Gavrilo8 (m_gavrilo@mail.ru), G.A. Shipulin1 (shipulin@cmd.su) 1 Federal Budget Institution of Science «Central Research Institute of Epidemiology», Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow 2 Federal State Budget Institute of Science «Chumakov Institute of Poliomyelitis and Viral Encephalitides», Moscow 3 Federal State Budget Institute of Science «Research Institute of Occupational Health», Moscow 4 Federal Budget Institution of Science «Institute for Natural Foci Infections», Omsk, Russian Federation 5 State Autonomous Educational Institution of Higher Professional Education «Far Eastern Federal University», Vladivostok, Russian Federation 6 Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation 7 Federal Budget Institution of Science «Omsk State Pedagogical University, Omsk», Russian Federation 8 Federal State Budget Institute «National Park «Russian Arctic», Archangelsk, Russian Federation
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