Abstract
Objective To understand the molecular epidemiology of norovirus from 5 outbreaks of gastroenteritis during Dec. 2012 to Jan. 2013 in Guangzhou. Methods Epidemiologic data and specimens were collected from 5 gastroenteritis outbreaks in Guangzhou. 274 specimens were detected for norovirus by RT-PCR methods and PCR products were sequenced. Sequence alignment and phylogenetic analysis were performed by using Clustal X 1.83 and MEGA 5.05 programs. Statistical analysis was performed by using SPSS 17.0 program. Results The total positive rate of norovirus was 20.07% (55/274). The positive rate was 8.70% (2/23) in University A, 36.36% (8/22) in Kindergarten B, 36.07% (22/61) in University C, 100% (5/5) in community health service center D, 11.04% (18/163) in University E. The positive rate was 100% (6/6) among age group ≥ 60 years old, 47.37% (9/19) among 10-19 age group and 36.36% (8/22) among age group<10 years old. Phylogenetic analysis showed that 33 samples were infected by the new variant-Sydney 2012 of norovirus GII.4. Conclusion Norovirus was one of the main pathogens causing acute gastroenteritis outbreaks and GII.4 Sydney 2012 variant was identified as the predominant strain in Guangzhou. Key words: Norovirus; Acute gastroenteritis; Outbreak; Sydney 2012 variant
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