Abstract
HTLV-1 molecular epidemiological studies demonstrated its great genetic stability, with different subtypes/subgroups, linked to the geographical origin. These peculiar features can be used as molecular means to study migrations of HTLV-1 endemic populations. Although the Caribbean archipelago is a high HTLV-1 endemic area, little is known concerning the HTLV-1 genetic diversity in this region.
Highlights
HTLV-1 molecular epidemiological studies demonstrated its great genetic stability, with different subtypes/ subgroups, linked to the geographical origin. These peculiar features can be used as molecular means to study migrations of HTLV-1 endemic populations
Materials and methods HTLV-1 infected persons, either patients or HTLV-1 asymptomatic carriers, mostly living in Paris area, were included. Their geographical origin was determined through interviews
Comparison of the complete LTR indicated that most of the West African strains were of the Senegal subgroup or West African one (AWA)
Summary
Molecular epidemiology of HTLV-1 infection in the caribbean area as compared to West Africa: relationship with the slave trade. Alexandra Desrames1*, Olivier Cassar, Philippe V Afonso, Olivier Gout, Olivier Hermine, Antoine Gessain1*. From 15th International Conference on Human Retroviruses: HTLV and Related Viruses Leuven and Gembloux, Belgium. From 15th International Conference on Human Retroviruses: HTLV and Related Viruses Leuven and Gembloux, Belgium. 5-8 June 2011
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