Abstract
The HCV genome is highly heterogeneous, owing to the high mutation rate of RNA viruses. There are seven HCV genotypes, with numerous subtypes and viral quasispecies. The prevalence and distribution of HCV genotypes varies globally, and strains show highly variable sensitivity to available therapeutics. Thus, genetic and epidemiological studies of hepatitis C infection are significant, especially within high-risk cohorts where viral evolution can be rapid and unpredictable.
Highlights
The HCV genome is highly heterogeneous, owing to the high mutation rate of RNA viruses
21 out of 64 research subjects (32.8%) were positive for HCV, a percentage much lower than the global average (60%) amongst intravenous drug users (IVDU)
38% of the subjects were infected with strain 1b, which is fairly uncommon amongst IVDUs
Summary
The HCV genome is highly heterogeneous, owing to the high mutation rate of RNA viruses. There are seven HCV genotypes, with numerous subtypes and viral quasispecies. The prevalence and distribution of HCV genotypes varies globally, and strains show highly variable sensitivity to available therapeutics. Genetic and epidemiological studies of hepatitis C infection are significant, especially within high-risk cohorts where viral evolution can be rapid and unpredictable
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