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Abstract
IntroductionHuman noroviruses are the leading cause of acute viral gastroenteritis (AGE) worldwide in all age groups. GII.4 strains have been the predominant genotype circulating globally over the last 2 decades and since 2012. GII.4 Sydney viruses have emerged and caused the majority of AGE outbreaks worldwide.MethodsData from norovirus outbreaks from the laboratory-based surveillance of norovirus outbreaks in China (CaliciNet China) between October 2016–December 2020 were analyzed.ResultsDuring October 2016–December 2020, 1,954 norovirus outbreaks were reported, and positive fecal samples from 1,352 (69.19%) outbreaks were genotyped. GII.4 Sydney [P31] viruses accounted for 2.1% (October 2016–August 2017), 5.5% (September 2017–August 2018), 3.3% (September 2018–August 2018), 26.6% (September 2019–August 2020), and and 1.1% (September 2020–December 2020) of GII outbreaks, respectively. Compared to reference strains of GII.4 Sydney [P31] from 2012 to 2013, 7 amino acid mutations in epitopes[A (297, 372 and 373), B (333), E (414), and H (309 and 310)] and 1 in human histo-blood group antigens binding site at site II 372 were found by analyzing 9 GII.4 Sydney [P31] complete genomic sequences.ConclusionsThis report identified the genomic variation of GII.4 Sydney [P31] from CaliciNet China. Continued surveillance with prompt genotyping and genetic analysis is necessary to monitor the emergence of novel GII.4 variants.
Highlights
ResultsDuring October 2016–December 2020, 1,954 norovirus outbreaks were reported, and positive fecal samples from 1,352 (69.19%) outbreaks were genotyped
Human noroviruses are the leading cause of acute viral gastroenteritis (AGE) worldwide in all age groups
This report identified the genomic variation of GII.4
Summary
During October 2016–December 2020, 1,954 norovirus outbreaks were reported, and positive fecal samples from 1,352 (69.19%) outbreaks were genotyped. Sydney [P31] viruses accounted for 2.1% (October 2016–August 2017), 5.5% (September 2017–August 2018), 3.3% (September 2018–August 2018), 26.6% (September 2019–August 2020), and and 1.1% (September 2020–December 2020) of GII outbreaks, respectively. Sydney [P31] from 2012 to 2013, 7 amino acid mutations in epitopes[A (297, 372 and 373), B [333], E [414], and H (309 and 310)] and 1 in human histo-blood group antigens binding site at site II 372 were found by analyzing 9 GII.. Compared to reference strains of GII. Sydney [P31] from 2012 to 2013, 7 amino acid mutations in epitopes[A (297, 372 and 373), B [333], E [414], and H (309 and 310)] and 1 in human histo-blood group antigens binding site at site II 372 were found by analyzing 9 GII. Sydney [P31] complete genomic sequences
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