Abstract
a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.
Highlights
Glucagon-like Peptide-1 (GLP-1), which is a known incretin hormone synthesized from the lower gut, plays a role in modulating glycemic control and can be used in glucose-lowering medication for type-2 Diabetes Mellitus (T2DM).[1]
The purpose of this study is to evaluate the mechanism of action of soybean seed extract and ginger rhizome as an anti-diabetic through inhibitory activity of both Dipeptidyl peptidase-4 (DPP-4) and α-glucosidase using in silico study
Identification of active substances in Glycine max and Zingiber officinale Extract The active compounds from ethanol extract of soybean seeds and ginger rhizomes using the LC-MS/MS method can be seen in Figure 3, Figure 4, and Table 1
Summary
Glucagon-like Peptide-1 (GLP-1), which is a known incretin hormone synthesized from the lower gut, plays a role in modulating glycemic control and can be used in glucose-lowering medication for type-2 Diabetes Mellitus (T2DM).[1]. 3 alpha-glucosidases (α-glucosidases) are enzymes that are responsible for the conversion of complex carbohydrate into maltose, dextrin and maltotriose.[4] These enzymes are commonly found in the brush border of the small intestines, whereas the products of carbohydrate metabolism are delivered into the small intestinal mucosa, and absorbed into blood circulation.[5] α-glucosidases activity contributes in increasing blood glucose level post prandially, and needs to be controlled to avoid hyperglycemia. Inhibition of both DPP-4 and α-glucosidase could be used in preventing the increase of blood glucose level, especially for patients with T2DM.[3,4]
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