MOLECULAR DOCKING OF BREAST CANCER RECEPTORS AGAINST  ANTI-CANCER DRUG SOLASODINE

Abstract

Cancer is a deadly disease that occurs in skin, pancreas, breast, and other body   parts. Breast cancer is nowadays more common and can develop from various   cell lines like MCF-7, MDA-MB-231, BT-20, etc. Early diagnosis and treatment   can reduce the frequency of fatalities due to breast cancer, but early cancer   screenings are often postponed due to erroneous information, fear, and   ignorance. In the present work, we used molecular docking to find out the   effect of solasodine binding on different cancer receptors. Solasodine was   extracted from black nightshade (Solanum nigrum), a weed that was long used   against stomach ache in Ayurveda. The isolated solasodine was even used in   ointments against skin cancer. Docking such a medicinally potent compound   resulted in positive response against a few receptors like Farnesoid X,   epidermal growth factor receptor and progesterone receptor. MCF-7 breast   cancer cell line was chosen for further ex-vivo studies and the results of MTT   assay showed significant anti-cancer effects at solasodine concentrations of 500   and 1000 µg mL-1. These findings indicated that Solasodine was a vital   candidate as drug against breast cancer.