Abstract
A significant soluble protein, specifically bovine serum albumin (BSA) plays an efficient role in drug delivery, and etoposide (ETS) is used to cure various cancers. Binding interaction between ETS and BSA examined by 3D, emission, synchronous fluorescence’s, UV–vis, FT–IR, and CD spectroscopy’s in the association of computational at pH 7.40 with 293, 301 and 309 K. Formed complex between ETS and BSA dominates van der Waals and bonding of hydrogen’s at sub-domain IIIA. Strong binding of ETS-BSA leads to altering BSA’s structural and conformations statically. Energy transfer reveals ETS-BSA distance. Apart from this, ETS-BSA binding is affected by Mg2+, Cu2+, Fe2+, Ca2+, and Co2+ ions. This study may help in the drug development and discovery process.
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