Molecular Docking Analysis of Phytochemicals from Tinospora Cordifolia as Potential Inhibitor against SARS CoV- 2

Abstract

Abstract: Since the beginning of time, the Indian system of medicine (ISM) and traditional Ayurvedic medicine have employed tinospora cordifolia, also known as giloy. In ayurveda, the plant is known as Rasayana and is highly regarded for boosting the body's defences against specific infectious microorganisms. Of the 40 species, only 4 are found in India. It is a perennial herbaceous vine that is a member of the Menispermaceae genus. It is frequently utilised as a distinctive component of several natural medicines and has been used traditionally for a wide range of illnesses, including fever, vomiting, diabetes, jaundice, anaemia, polyuria, and skin conditions. Instead of treating the disease's cause, plant-based medicine actually balances the body. Due to a lack of effective treatment options, the coronavirus strain (SAR-CoV-2) will become more dangerous. Ayurveda is a style of ancient medicine that offers a holistic approach to treating this illness. The only defence against the coronavirus illness, which is spreading like wildfire, is "immunity." The only way to keep healthy and safe while preparing for the impending epidemic is to build immunity. Good immunity protects us from disease progression and the spread of this dangerous virus in the current situation. Due to its immunomodulatory and antiviral properties, giloy herb gained popularity after the COVID-19 pandemic began. Keap1 keeps Nrf2 in check by securing it in its protein complex. Additionally, Keap1 aids in the ubiquitinationmediated degradation of Nrf2. Keap1 is a down-regulator of Nrf2, in other words. Keap1 must be suppressed and Nrf2 must be released in order to increase the production of biological antioxidants. Since freed Nrf2 is unbound, it moves to the nucleus to activate the antioxidant response element (ARE) found on the genes encoding for antioxidants. Keap1 is a 624 amino acid residue long protein that belongs to the BTB (bric-a-brac, tram-track, and broad-complex) Kelch family. Antioxidant production should therefore be increased in such a situation. We have summarised the function of the Keap1-Nrf2 system in the synthesis of antioxidants in this review article. We also suggest its possible therapeutic application in controlling COVID-19's cytokine storm. This article focuses on molecular docking of KEAP-1-Nrf2, NRF-2 proteins to inhibit COVID- 19 disease.