Abstract
Fungal infections have been increasing in recent years due to growing number of high-risk patients particularly immuno compromised hosts. Candida is the third- or fourth-most-common isolate in nosocomial bloodstream infections. The increase of fungal resistance to classical drugs, the treatment costs, and the fact that most available antifungal drugs have only fungistatic activity, justify the search for new strategies. Identification of therapeutic compounds from plants has been the centre of attraction ever since they were discovered. It is of interest to document the molecular docking analysis of bioactive compounds present in Mollugo cerviana (L.) SER with the DHFR protein target for antifungal activity. We show the optimal binding features of several compounds from the extract with in vivo and in vitro activities. Results of this showed that all compounds showed good antimicrobial activity and a very good antifungal activity against the target DHFR protein. So, these compounds may act as potential drug molecules after the experimental validation.
Highlights
Fungal infection reports more than 1.5 million deaths annually worldwide [1]
The extract was more active against Aspergillus niger with IZD of 33.45 mm and it has less activity against Candida albicans with IZD of 24.51 mm
The results showed that the Minimum inhibitory concentration (MIC) values against the tested strains ranges from 10.5 μg/ml ‐ 15.5 μg/ml
Summary
Modern medicine provides many new prophylactic antifungal drugs to treat these infections. The antifungal properties of many new plant extracts with high efficiency have been reported [3, 4]. The chosen medicinal plant Mollugo cerviana (L.) SER is loaded with large number of phytochemicals and reported for its antibacterial, anifungal and anti-inflammatory activity [5]. This plant is used as a traditional medicine in south Indian Villages to treat fever, Stomach ache, Jaundice, improving eye sight and to regulate Blood Pressure and they exhibit good hepato protective. It is of interest to document the molecular docking analysis of these bioactive compounds in Mollugo cerviana (L.) SER with the DHFR protein target for antifungal activity
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