Abstract
Acetylcholinesterase (AChE) accumulates in neuromuscular junctions (NMJs) where it terminates synaptic transmission by hydrolyzing the neurotransmitter acetylcholine (ACh) (Salpeter, 1967). In addition, AChE is expressed in non-cholinergic tissues such as the hematopoietic system (Paulus et al., 1981), germ cells (Gundersen and Miledi, 1983), embryonic tissues at developmental stages before the onset of cholinergic transmission (Layer, 1991) and malignant tumors (Karpel et al., 1994). The role of AChE in these non-cholinergic tissues is unknown and is sometimes speculated to be non-catalytical. ACHE, the human gene encoding AChE, is located on the long arm of chromosome 7 (7q22) (Getman et al., 1992; Ehrlich et al, 1992), and spans a region of 7 Kb. Three 3′ — alternative splicing options yield 3 mature AChE mRNAs whose catalytically active protein products differ at their C-termini (Ben Aziz-Aloya et al., 1993; Karpel et al., 1994).
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