Abstract
Background The V3 loop of the env gene in HIV-C type is considered as a major viral determinant for coreceptor specificity. The tip motif of v3 loop is known for antibody neutralization, so sequence variation in this motif have an impact on virus infectivity and disease progression. So analysis of genetic diversity in the V3 loop Tip motif help us to improve the CCR5 antagonist’s development as well as vaccine target.
Highlights
The V3 loop of the env gene in HIV-C type is considered as a major viral determinant for coreceptor specificity
Molecular determinants analysis and co receptor tropism prediction of V3 loop of HIV-1 “C” clade sequences isolated from India using insilico approach
High prevalence of R5 tropism, higher no of conserved motif regions in the V3 sequence among HIV strains in India reveals the need of potential CCR5 antagonists
Summary
Molecular determinants analysis and co receptor tropism prediction of V3 loop of HIV-1 “C” clade sequences isolated from India using insilico approach. From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India. 20-22 January 2012
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