Abstract
Based on molecular modeling data, 2-adamantyl 8-[(2-methoxyestra-1,3,5(10)-triene-3,17β-diol-6α-yl)amino]octanoate 2d is proposed as a structural analogue of highly cytotoxic N-(8-(adamant-2-yloxi)-8-oxooctanoyl)-N-deacetylcolchycine. Three-step synthesis of adamant-2-yl 8-aminooctanoate 5 is described. Reductive amination of 2-methoxy-6-oxo-17β-estradiol in weakly acidic medium in the presence of compound 5 and NaBH3CN or Na(OAc)3BH results in the product of elimination at the C6–C7 bond of steroid 7 rather than the formation of conjugate 2d.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
