Abstract
The primo vascular system (PVS) has been found in various cancer models, such as the lung cancer, ovarian cancer, and melanoma models. However, there have been no investigations to discriminate PVS from the similar-looking lymphatic vascular system (LVS) in melanoma models. In the present study, the compositional differences between the PVS and the LVS were investigated in murine melanoma models by using immunofluorescence staining and ultra-performance liquid-chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF MS). Primo vessels (PVs) and primo nodes (PNs) were found on the surface of a cutaneous melanoma by using Trypan blue staining. An immunofluorescent study revealed that the PVs did not contain LYVE-1, a specific endothelial antigen of lymphatics. UPLC-Q-TOF MS chromatograms clearly showed different ion mass peaks between the two vascular systems. Taken together, the presented data on the compositional differences suggest that the PVS is an entirely different circulation system from the LVS.
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