Abstract
We have shown earlier (1) that chromosomes contain RNA which is associated with the chromosomal proteins, the majority of which are histories. In pea chromatin these RNA molecules are approximately 40 nucleotides in length, contain about 27 mole per cent dihydrouridylic acid, and are associated with chromosomal DNA in such a way that they are protected from attack by RNase. As a first step in the study of the role of this class of RNA we have investigated the characteristics of its hybridization with nuclear DNA. It is shown below that the RNA component of protein-bound chromosomal RNA is heterogeneous and that it hybridizes with 5 per cent of nuclear DNA, a ratio approximating the ratio of this RNA to DNA in native chromatin.
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