Abstract
We report the novel cloning of the murine PHEX promoter, the gene that is mutated in X-linked hypophosphatemic rickets (XLH). Four promoter/reporter gene constructs, −133/+104, −542/+104, −1061/+104, and −2866/+104, showed significant luciferase activity (4.9–13.2-fold over background) when transfected into rat osteogenic sarcoma (UMR-106) cells.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
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