Abstract
We report the novel cloning of the murine PHEX promoter, the gene that is mutated in X-linked hypophosphatemic rickets (XLH). Four promoter/reporter gene constructs, −133/+104, −542/+104, −1061/+104, and −2866/+104, showed significant luciferase activity (4.9–13.2-fold over background) when transfected into rat osteogenic sarcoma (UMR-106) cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have