Molecular Cloning of Porcine DIS3L2 Gene and Association between a SNP with Litter Size Trait

Liu Yonggang

doi:10.26717/bjstr.2020.32.005311

Abstract

Liu Zang1-3 and Liu Yonggang3* Author Affiliations 1Yunnan Key Laboratory of Fertility Regulation and Minority Birth Health, Kunming 650021, China 2National Health and Family Planning Key Laboratory of Preconception Health in Western China, Kunming 650021, China 3Key Laboratory of Animal Nutrition and Feed of Yunnan Province, Yunnan Agricultural University, Kunming 650201 China Received: December 15, 2020 | Published: December 23, 2020 Corresponding author: Liu Yonggang, Key Laboratory of Animal Nutrition and Feed of Yunnan Province, Yunnan Agricultural University, Kunming 650201 China DOI: 10.26717/BJSTR.2020.32.005311

Highlights

DIS3 mitotic control-like protein (DIS3L2) is similar in sequence to 3’/5’ exonucleolytic subunits of the RNA exosome
DIS3L2 is a tumor related gene for prior experiment indicated that DIS3L2 overexpression suppressed the growth of human cancer cell lines, and knockdown enhanced the growth of these cells
Both the total number of piglets born (TNB) and the number of piglets born alive (NBA) of 200 Large White sows and 200 Landrace sows listed in Table 1 were recorded for 700 litters

Summary

Introduction

DIS3 mitotic control-like protein (DIS3L2) is similar in sequence to 3’/5’ exonucleolytic subunits of the RNA exosome. DIS3L2 is a tumor related gene for prior experiment indicated that DIS3L2 overexpression suppressed the growth of human cancer cell lines, and knockdown enhanced the growth of these cells. DIS3L2 is an important development and reproduction related gene for it has been identified to be associated with the adult human height and mouse embryo development [2,3,4,5]. Latest studies have shown that DIS3L2 gene has more important functions such as biological processes and metabolic processes of RNA binding, hydrolase activity, exonuclease activity, nuclease activity, molecular function, ribonuclease activity [6,7]. DIS3L2 gene is an important gene which has many biological functions. DIS3L2 gene has been reported in human [8], cattle [5] and other animals, but, the swine DIS3L2 gene has not been reported yet

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