Abstract
Interferon (IFN) is biological substance showing antiviral activity, whose main ingredient is protein. Many mammalian IFNs have been reported, and some human IFNs (HuIFNs) are commercially manufactured for anticancer and antiviral drugs. As to IFNs of companion animals, genes of equine IFN (1) and canine IFN (1) have been cloned and expressed in E. coli. In the case of cats, applications of HuIFN alpha were reported to be effective in vivo within some extent to feline leukaemia virus (2), feline herpes virus (3). The limitation of the application is generation of endogeneous neutralizing antibody against HuIFN in cat. So we produced pyrogen-free recombinant FelFN (rFelFN) using monkey cell COS by transient expression method after cloning of FelFN cDNA (4). According to Dr. J. K. Yamamoto (5), our rFelFN was effective in reducing clinical symptons of SPF cats induced by the challege infection of feline herpes virus or feline calicivirus, and generation of neutralizing antibody was not found by intravenous route.
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