Abstract
Alpha 1-acid glycoprotein (AGP) complementary DNA clone has been isolated from an acute phase rabbit liver library. Complete and full-length nucleotide sequence of this cDNA has been determined. The cDNA contains 35 nucleotides 5′ untranslated region followed by 606 nucleotides of coding region and a 112 nucleotides 3′ untranslated region. Comparison of this sequence with that of human, rat and mouse reveals a high degree of homology with human α 1-AGP. Northern blot analysis of messenger RNA for α 1-AGP in normal and acute livers demonstrates remarkable induction of transcription of this gene in rabbit in response to acute inflammation by the administration of turpentine. Such a response of AGP gene expression makes it a major member of the acute phase responsive genes in rabbit liver.
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