Abstract
The RT6 system (1) was first detected and serologically defined on peripheral T cells of different inbred strains of the Norway rat (2-6). It gained particular interest when it was reported that the diabetes-prone BioBreeding rat (DP-BB), which develops insulindependent diabetes mellitus (IDDM) between postnatal day 60 and 120 in a high frequency, does not appropriately express RT6 on the surfaces of its T cells (7). Subsequently RT6 -homologous genes were also detected in mice, primates and some other species (8, 9).
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