Abstract
Journal of Diagnostic Pathology is a peer reviewed journal published biannually by the College of Pathologists of Sri Lanka. The journal publishes manuscripts dealing with all aspects of pathology. The aim of the journal is to update knowledge and encourage original research in the field of pathology.
Highlights
Breast cancer, the most common cancer among females worldwide has significant morbidity and mortality
This paper aims to describe the distribution of molecular subtypes and document the survival pattern according to the molecular classification in a cohort of breast cancer patients in Sri Lanka
Construction of Tissue Micro Arrays (TMA) Tissue blocks were first examined for their physical suitability and a histopathologist reviewed the Haematoxylin and Eosin (H&E) stained slides of each case
Summary
The most common cancer among females worldwide has significant morbidity and mortality. It is accepted as a heterogeneous disease at biological, morphological, and clinical levels. Breast cancers with similar morphology may have varying prognostic attributes resulting in varying response to treatment and prognosis. This necessitates developing a classification to identify homogenous subsets of patients to offer tailor made therapy. Normal-like subtype was later removed as identifying this subgroup and its consequences are not clear It was assumed this subtype represented samples of low tumor cell content with normal tissue components in genetic expression analysis [4].
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