Abstract
Human echovirus 18 (E-18) is a member of the enterovirus B species. To date, sixteen full-length genome sequences of E-18 are available in the GenBank database. In this study, we describe the complete genomic characterization of two E-18 strains isolated in Yunnan, China. Pairwise comparisons of the nucleotide sequences and the deduced amino acid sequences revealed that the two Yunnan E-18 strains had 87.5% nucleotide identity and 96.3–96.5% amino acid identity with the Chinese strain. Phylogenetic and bootscanning analyses revealed the two E-18 strains had the highest identity with other several EV-B serotypes than the other E-18 strains in the P3 coding region, especially, 3B region of the Swine Vesicular disease virus (SVDV) strain HK70, indicated that frequent intertypic recombination might have occurred in the two Yunnan strains. This study contributes the complete genome sequences of E-18 to the GenBank database and provides valuable information on the molecular epidemiology of E-18 in China.
Highlights
The genus Enterovirus, within family Picornaviridae, order Picornavirales, can be divided into 13 species: enterovirus A–J, and rhinovirus A–C, comprising more than 100 serotypes
Outbreaks of aseptic meningitis caused by echovirus 18 (E-18) have been frequently reported[10,11,12,13,14,15,16]
Isolated in the Yunnan province of China in 2016 from two children with hand-foot-and-mouth disease (HFMD) aged 5 and 4.2 years, respectively. This is the first report of E-18 and its probable association with HFMD
Summary
The genus Enterovirus, within family Picornaviridae, order Picornavirales, can be divided into 13 species: enterovirus A–J, and rhinovirus A–C (www.picornaviridae.com), comprising more than 100 serotypes. Though the majority of clinical symptoms are asymptomatic or mild, such as fever, irritation, agitation, sore throat, headache, myalgia, vomiting, diarrhoea, hand-foot-and-mouth disease (HFMD) and others, a few patients may develop severe neurological syndromes as aseptic meningitis, acute flaccid paralysis (AFP), hypertensive heart failure (HHF), dilated cardiomyopathy and death[5]. Of these symptoms, the viruses of species EV-B are the most common viral cause of aseptic meningitis[6,7,8]. This is the first report of E-18 and its probable association with HFMD
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