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Abstract
BackgroundOrf or contagious ecthyma is a zoonotic viral infection with a potential serious health threat for the small ruminants industry as well as humans. It is currently emerging in new territories.ResultsEight suspected clinical cases of pustular dermatitis in goats occurred in the rural area of Tebe, in south-eastern Gabon, in January 2013. The orf virus (ORFV) was detected by high-throughput sequencing on sera, buccal swabs and scab pool samples. It was confirmed in six out of eight sick goats by using specific PCR targeting the major envelope protein (B2L) and the orf virus interferon resistance (VIR) genes. Phylogenetic analysis revealed that the Gabonese strain and South Korean strains evolved from a common ancestor, suggesting an Asian origin of the ORFV’ Gabonese strain.ConclusionsThis study provides the molecular detection of the ORFV strain involved in the cases of pustular dermatitis in goats and highlights its circulation in Gabon.
Highlights
Orf or contagious ecthyma is a zoonotic viral infection with a potential serious health threat for the small ruminants industry as well as humans
We report the first cases of orf infection causing a small outbreak of pustular dermatitis in goats in south-eastern Gabon and the molecular characterization of the viral strain
We provide, in this study, the first clinical description and genetic characterization of the orf infection involved in an outbreak in goats from a rural area in southeastern Gabon
Summary
Orf or contagious ecthyma is a zoonotic viral infection with a potential serious health threat for the small ruminants industry as well as humans. It is currently emerging in new territories. Orf or contagious ecthyma is a zoonotic viral infection caused by an enveloped double stranded DNA virus, the orf virus (ORFV) belonging to the Poxviridae family, Chordopoxvirinae subfamily, Parapoxvirus genus. This infectious pustular dermatitis primarily affects sheep, goats and wild ruminants worldwide [1].
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