Abstract
Canine kobuvirus (CaKVs) was a newly described virus detected in dogs in the US and Italy. To learn more about CaKVs, 5 of 106 fecal samples from diarrhea dogs were positive with CaKVs in China, and the full genome of CaKVs strain CH-1 isolated from dog with diarrhea was sequenced. The genome consists of 8186 nucleotides, excluding the 3′ poly (A) tail, and an open reading frame that maps between nucleotide positions 601 and 7943 which encodes a 2446 amino acid polyprotein. Based on the complete amino acid sequence of polyprotein, phylogenetic analysis showed that CH-1 was grouped along with other canine kobuvirus strains detected in the USA (US-PC0082, AN211D).
Highlights
Picornaviruses belonging to Picornaviridae family are small, nonenveloped viruses with a single-stranded positive-sense RNA genome encoding a single polyprotein, which is genetically highly diverse and infects a wide range of vertebrate species including human and animal
The species Aichivirus A consists of four types: Aichi virus 1, canine kobuvirus 1 (Kapoor et al 2011; Li et al 2011), feline kobuvirus 1 (Chung et al 2013) and murine kobuvirus 1 (Phan et al 2011)
The complete genome of one strain Canine kobuvirus (CaKVs) named CH-1, was detected and sequenced using 6 pair of primers designed basing on the genome of CaKV/AN211D/ US
Summary
Picornaviruses belonging to Picornaviridae family are small, nonenveloped viruses with a single-stranded positive-sense RNA genome encoding a single polyprotein, which is genetically highly diverse and infects a wide range of vertebrate species including human and animal. The Kobuvirus which was identified as a newly genus in the family Picornaviridae, consists of three species, Aichivirus A (formerly Aichi virus) (Yamashita et al 1998), Aichivirus B (formerly Bovine kobuvirus) (Yamashita et al 2003) and Aichivirus C (porcine kobuvirus) (Reuter et al 2009). The species Aichivirus A consists of four types: Aichi virus 1, canine kobuvirus 1 (Kapoor et al 2011; Li et al 2011), feline kobuvirus 1 (Chung et al 2013) and murine kobuvirus 1 (Phan et al 2011). The species Aichivirus C consists of a single type: porcine kobuvirus 1 (Reuter et al 2008).
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