Abstract
Acinetobacter baumannii is an opportunistic microorganism commonly found in intensive care units (ICUs), and it is responsible for a broad span of hospital-acquired infections. Persistence of nosocomial infection caused by multidrug-resistant (MDR) A. baumannii is an alarming health care issue in Egypt, and at present, colistin remains the treatment of choice for the management of MDR A. baumannii infections. A. baumannii possesses great capacity to develop and acquire resistance to a broad range of antibiotics. The acquisition and dissemination of antibiotic-resistant determinants in A. baumannii strains are mediated by integrons, especially class I integrons. This study focuses on the characterization of some genetic mechanisms underlying the multidrug-resistant phenotypes of A. baumannii isolates in Egypt. Forty-eight A. baumannii specimens were isolated from different hospitalized patients; least resistance was observed against amikacin and tigecycline, with 60% and 58.5% of the isolates resistant, respectively, whereas 62.5% of the isolates were resistant to imipenem and meropenem. The highest sensitivity was found for colistin. Genetic analysis revealed that blaoxa-51 was detected in all isolates, the blaoxa-23-like gene was detected in 80% of the isolates, and blaoxa-24 and blaoxs-58 were not detected in any isolate. Finally, PCR analysis revealed that 6.6% of isolates carried the class I integron gene.
Highlights
Acinetobacter baumannii is an opportunistic microorganism commonly found in intensive care units (ICUs)
The primary factor leading to the wide spread of this nosocomial microorganism is its capacity for possessing a broad spectrum of antibiotic resistance genes
The minimum inhibitory concentration (MIC) values for carbapenems were above 32 μg / mL for (30) 62 . 5% of isolates, and above 128 μg/mL, 256 μg/mL and 128 μg/
Summary
Acinetobacter baumannii is an opportunistic microorganism commonly found in intensive care units (ICUs). It is responsible for a broad range of infections such as urinary tract infections, surgical wound infections, ventilator-associated pneumonia, meningitis, bacteremia, and other life-threatening infections. The primary factor leading to the wide spread of this nosocomial microorganism is its capacity for possessing a broad spectrum of antibiotic resistance genes. Selective pressure due to environmental stress causes the prevalence of these antibiotic-resistant clones[1]. Its broad assortment of antimicrobial resistance genes makes infections difficult to treat, thereby causing financial burdens that create problems in infection management in hospitals. The quickly increasing prevalence of multi-drug resistant
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