Abstract
Increasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. In this study, we evaluated the association between lncRNA and metabolic pathways and identified metabolism-related lncRNAs. Gastric cancer can be mainly subdivided into 2 clusters based on these metabolism-related lncRNA regulators. Comparative analysis shows that these subtypes are found to be highly consistent with previously identified subtypes based on other omics data. Functional enrichment analysis shows that they are enriched in distinct biological processes. Mutation analysis shows that ABCA13 is a protective factor in subtype C1 but a risk factor in C2. Analysis of chemotherapeutic and immunotherapeutic sensitivity shows that these subtypes tend to display distinct sensitivity to the same chemical drugs. In conclusion, these findings demonstrated the significance of lncRNA in metabolic regulation. These metabolism-related lncRNA regulators can improve our understanding of the underlying mechanism of lncRNAs and advance the research of immunotherapies in the clinical management of gastric cancer.
Highlights
Increasing evidence has demonstrated that Long non-coding RNAs (lncRNA) are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored
We investigated the association between ABCA13 and these 100 lncRNAs used for classification and found that some lncRNAs tend to be correlated with ABCA13 mutant
We identified metabolism-related lncRNA
Summary
Increasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. We evaluated the association between lncRNA and metabolic pathways and identified metabolism-related lncRNAs. Gastric cancer can be mainly subdivided into 2 clusters based on these metabolism-related lncRNA regulators. Analysis of chemotherapeutic and immunotherapeutic sensitivity shows that these subtypes tend to display distinct sensitivity to the same chemical drugs These findings demonstrated the significance of lncRNA in metabolic regulation. Cancer metabolism research revealed that metabolic profiles of individual tumors are highly h eterogenous[13] and metabolic expression subtypes of human cancers are significantly associated with patient survival[14]. All of these studies concentrated on protein-coding genes.
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