Abstract
Background: The Kidd glycoprotein is expressed in the kidney, where it enables the kidney to build up a high concentration of urea, which is needed for the kidney to produce concentrated urine. The urea transport across Kidd null RBC membranes is ~1000 times slower than across normal RBC membrane. Chronic kidney disease develops slowly and, initially, show few symptoms. CKD can be the long term consequence of irreversible acute disease or part of a disease progression. The most common causes of chronic renal failure are related to poorly controlled diabetes, poorly controlled high blood pressure.
 Objective: the aim of this study was to assess the association between the Kidd antigen polymorphism and chronic kidney disease, in Sudan.
 Results: The distribution of kidd blood group between chronic kidneydisease patient and control group were (49%) and (50%) for Jk (a + b−), 40% and 44% for Jk (a + b+) and 11% and 6% Jk (a − b+) respectively. also there were different in ten samples represented genomic typing (Jk ab ) but phenoptying represented as (Jka).
 Conclusion: There were no obvious effects of kidd antigens polymorphism on kidney function .
 Keywords: Kidd blood group, Genomic typing, Phenotyping, Chronic kidney disease.
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