Abstract
We collected β-hemolytic streptococci (1,611 isolates) from patients with invasive streptococcal infections in Japan during April 2010-March 2013. Streptococcus dysgalactiae subsp. equisimilis (SDSE) was most common (n = 693); 99% of patients with SDSE infections were elderly (mean age 75 years, SD ±15 years). We aimed to clarify molecular and epidemiologic characteristics of SDSE isolates and features of patient infections. Bacteremia with no identified focus of origin and cellulitis were the most prevalent manifestations; otherwise, clinical manifestations resembled those of S. pyogenes infections. Clinical manifestations also differed by patient's age. SDSE isolates were classified into 34 emm types; stG6792 was most prevalent (27.1%), followed by stG485 and stG245. Mortality rates did not differ according to emm types. Multilocus sequence typing identified 46 sequence types and 12 novel types. Types possessing macrolide- and quinolone-resistance genes were 18.4% and 2.6%, respectively; none showed β-lactam resistance. Among aging populations, invasive SDSE infections are an increasing risk.
Highlights
Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)TM
To clarify relationships between emm type and clonal complex (CC), we identified a dominant CC for each emm type
multilocus sequence typing (MLST) analysis indicated that CC17, consisting of ST17, was the most prevalent CC, which was identified in a variety of emm types
Summary
LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)TM. All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: [1] review the learning objectives and author disclosures; [2] study the education content; [3] take the post-test with a 75% minimum passing score and complete the evaluation at http://www.medscape.org/journal/eid; [4] view/print certificate. Distinguish clinical characteristics of Streptococcus dysgalactiae subsp. Equisimilis infections, based on a study of isolates from Japanese patients with invasive streptococcal infections. . Identify the characteristics of antibiotic resistance genes of Streptococcus dysgalactiae subsp. Equisimilis isolates from Japanese patients with invasive streptococcal infections Identify the characteristics of antibiotic resistance genes of Streptococcus dysgalactiae subsp. equisimilis isolates from Japanese patients with invasive streptococcal infections
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
