Molecular characterization of HLA-A mismatches for modeling outcomes analyses

Abstract

For allogeneic transplant candidates who have no HLA matched donor, there are no well accepted guidelines for selecting an HLA mismatched (MM) donor. To provide a foundation for developing new models for ranking HLA MM donors, this investigation focuses on HLA-A MM because single HLA-A MM are observed in a large proportion of patients. The molecular characteristics of 832 HLA-A MM were examined in 3,687 unrelated donor-recipient pairs from NMDP facilitated transplants which had retrospective high resolution HLA typing.