Abstract
Tapasin, TAP1 and TAP2 are involved in the assembly of MHC class I molecules. The genes encoding these three products belong to the Major Histocompatibility Complex: in chicken, Tapasin is located between the two class IIb genes, while TAP1 and TAP2 are found between the two class I genes. The current study aimed at the molecular characterization of these three genes. Starting from Single Nucleotide Polymorphisms (11 in Tapasin, 18 in TAP1 and 21 in TAP2) previously discovered by the authors within these genes, the nucleotide diversity was assessed at each locus. Moreover, the haplotypes were reconstructed for each individual and the genetic distances between the chicken lines and breeds were estimated. From the analysis of the nucleotide diversity values, variale polymorphism rates could be observed among the three genes. In the three analyzed loci the SNPsrates were higher than the reported chicken genome mean nucleotide diversity of 5 SNPs kb−1. The calculation of the genetic distances permitted, generally, the distinction of animals among the analyzed lines/breeds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
