The small intestinal mucosa is exposed to a wide variety of exogenous molecules. Forming the first line of immunological defense, Peyer’s patches (PP) play an important role in distinguishing between potentially harmful agents and common food ingredients within the ingesta as a major part of the gut-associated lymphoid tissue (GALT; Jung et al, 2010). Responsible for the uptake and transport of antigens to the underlying tissue is the overlying follicle-associated epithelium (FAE), which forms a boundary separating the lumen contents and immune cells. FAE lacks the subepithelial myofibroblast sheath, the basal lamina of FAE is more porous compared to VE, and the basolateral surface of M cells is enhanced by invagination, promoting a faster translocation of antigens (Neutra et al, 2001; Takeuchi and Gonda, 2004). Local differences in morphology such as the invagination of the basolateral membrane of M cells, the lack of the subepithelial myofibroblast sheath, and a more porous basal lamina promote a faster response to antigens (Takeuchi and Gonda, 2004). The selectivity of transcellular mechanisms, including antigen uptake by dendritic cells or ligand-specific transcytosis mediated via Toll-like receptors, might benefit from a stronger paracellular seal