Abstract

Tamoxifen provides a survival advantage for women with breast cancer (Early Breast Trialists Collaborative Group, 1992). Because of its proven clinical efficacy, there are approximately 2 to 3 million women receiving treatment in more than 70 countries. With such widespread use, it is impera¬tive that the scientific community develop an understanding of tamoxifen’s molecular mechanism of action so as to exploit the antitumor effects while minimizing side effects. By studying this effective cancer therapeutic, investigators will develop a better understanding of breast carcinogenesis, which may translate to superior treatment regimens.

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