Abstract

Highly organized and defined arrangement of DNA in the cell nucleus is an important contribution to a timely and spatially correct gene expression and the respective functioning of the eukaryotic cell. More and more information is gained upon this structural organization not only in the chromosomes of a mitotic or meiotic cell but also at the interphase stage (Heslop-Harrison and Bennett 1991). Detailed cytological investigations with improved multicolor fluorescent in situ hybridization (FISH; Lichter 1997) or oligonucleotide primed in situ labeling (PRINS; Menke et al. 1998) techniques have elucidated the higher-order structure of chromosomes within the cell nucleus. Here, we would like to concentrate on the role of repetitive DNA in maintaining this order.

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