Abstract
Oral cancer is one of the six leading cancers in the world and is a constant threat to the health sector in developing countries as well as developed ones. Late presentation, due to lack of awareness and invasive incisional biopsy is the crucial factor for this. Nowadays, scientists are trying to find out an easy and reliable method of early diagnosis of oral cancer and molecular biomarkers might be very helpful for that. This review was aimed to evaluate the published literature on molecular biomarkers which are related to oral cancer. For this, advanced searching was applied by specific keywords in PubMed-Medline resource database and found 12466 publications were clinical trials on humans. Then after applying all inclusion criteria, 19 articles were included finally in the review. This paper uncovered that recognition of biomarkers will be useful for the early detection of oral cancer and their prognosis after treatment. We can suggest that p53, EGFR, miR-34a, miR-143 estimation is important to decide the conceivable risk of oral malignant growth advancement in the speculated oral lesion and after the curative procedure EGFR, Podoplanin and miR-21can aid us regarding the prognosis of patient.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 11-16
Highlights
Oral cancer is a constant threat to health services in developing countries as well as developed ones
This is an invasive, painful and costly procedure so there is low patient acceptance.4Molecularbiomarkers are ideal for the screening of oral lesions and diagnosis of oral cancer
Biomarkers are molecules that recognize the presence of a tissue
Summary
Oral cancer is a constant threat to health services in developing countries as well as developed ones It is the 6th most common of all cancers and more than 405,000 cases are registered annually.[1] If Cancer involves the visible parts of the oral cavity such as the lip, the tip of the tongue, it can be diagnosed. When it involves the posterior one-third of the tongue, retromolar area and the areas that can’t be visible it delays the diagnosis. The aim of the article is to review the findings of the clinical trials based on the oral cancer biomarkers
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