Molecular biomarker expression within window of opportunity studies for oestrogen receptor-positive breast cancer

Abstract

Introduction: Window of opportunity trials allow the opportunity to demonstrate pharmacodynamic parameters of a drug in vivo and are increasingly used in the context of breast cancer. Most breast cancer tumours are oestrogen receptor-positive (ER+), and multiple treatment options exist for this tumour subtype. The aim of this systematic review was to collate window of opportunity trials pertaining to the pharmacodynamic activity of drugs available for use in oestrogen receptor-positive breast cancer.