Abstract
Squamous cell carcinomas (SCCs) appear as firm tan or white tumors on gross examination. On histopathology, SCC is classified into well, moderate, and poorly differentiated by the level of squamous differentiation. Well-differentiated SCC has prominent intercellular bridges, dyskeratotic squamous cells, and keratin pearls. Poorly differentiated SCC has minimal squamous differentiation morphologically and needs of immunohistochemistry for confirmation of the diagnosis. Cytokeratin 5/6, p63, and p40 are useful immunohistochemical markers to confirm squamous differentiation in these cases. Moderately differentiated SCC shows evidence of squamous differentiation in a smaller proportion of the tumor than well-differentiated SCC. Grading of SCC does not significantly impact prognosis.
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