Abstract
In the past few years molecular biology has contributed to the ongoing research on the transthyretin (TTRj related amyloidoses. Several non exclusive intervening factors in amyloidogenesis are investigated by these techniques; they include the amyloidogenic potential of TTR, due to either modifications on the conformation of the protein and/or proteolysis at specific and constant sites, and finally interaction with tissue or circulating factors. Newer tools like PCR technology, genetic engineering in bacteria and transgenic animals are now used to approach the pathogenic mechanisms underlying these diseases.
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