Abstract
INTRODUCTION Many surgeons, if pressed, would probably maintain that molecular biology, or “molecular medicine”, has had little, if any, impact on their clinical practice. They might even confess to a degree of impatience, sometimes amounting to irritation, with the amount of “hype” given to an area of medical science that has promised much but delivered little in the fty years since the structure of DNA was explained. They are not alone. James LeFanu, general practitioner and medical journalist, savaged molecular genetics in his book The Rise and Fall of Modern Medicine.1 In a BBC interview he said:
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