Abstract
Purpose: to review the available data on molecular-genetic diagnostic and prognostic markers in prostate cancer. Material and methods. The following electronic databases were used for our systematic review: Medline, Cochrane Library and Elibrary. Of 540 studies, 61 were used for our systematic review. Results. There are currently a variety of both prognostic and diagnostic markers used for diagnosis and treatment of prostate cancer. The review presents the classification of markers depending on the method and medium in which they were identified. The molecular mechanisms of participation of the different genes and proteins in the pathogenesis and progression of prostate carcinoma were analyzed and the potential importance of their use in clinical practice was provided. Conclusion. Many of the existing markers can be used for screening and early detection of tumors, and they have been proved to have a prognostic value. However, contradictory findings with regard to certain proteins and genes require further study, their validation with the subsequent implementation into clinical practice.
Highlights
The following electronic databases were used for our systematic review: Medline, Cochrane Library and Elibrary
There are currently a variety of both prognostic and diagnostic markers used for diagnosis and treatment of prostate cancer
The review presents the classification of markers depending on the method and medium in which they were identified
Summary
MOLECULAR BIOLOGICAL FACTORS IN THE PREDICTION OF PROSTATE CANCER S.V. Vtorushin[1,2], N.V. Bezgodova[2], A.A. Pleshkunov[2]
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