Abstract
ALK-positive anaplastic large cell lymphoma is a heterogeneous group of mature T-cell non-Hodgkin lymphoma, and is characterized by CD30/Ki-1 expression. Recently, value of various prognostic factors is investigated. These include clinical, histological and molecular genetic changes associated with different signaling pathways activation. Some features of the mechanism of action of anaplastic lymphoma kinases and targeted therapies possibilities addressed in this review.
Highlights
Myakova Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev; 1 Samory Mashela St., Moscow 117997, Russia
ALK-positive anaplastic large cell lymphoma is a heterogeneous group of mature T-cell non-Hodgkin lymphoma, and is characterized by CD30/Ki-1 expression
Some features of the mechanism of action of anaplastic lymphoma kinases and targeted therapies possibilities addressed in this review
Summary
Введение ALK-позитивная анапластическая крупноклеточная лимфома (ALK+ АККЛ) представляет гетерогенную группу зрелых Т-клеточных неходжкинских лимфом с экспрессией СD30/Ki-1. ALK+ АККЛ впервые была выделена в самостоятельную нозологическую форму в конце 80-х годов прошлого столетия, когда в группе CD30-позитивных крупноклеточных анапластических лимфом была описана повторяющаяся транслокация t(2;5)(p23;q35) с последующей аберрантной экспрессией белка тирозинкиназы, названного впоследствии киназой анапластической лимфомы (anaplastic lymphoma kinase, ALK) [1]. Для опухолевых клеток характерна обязательная экспрессия антигенов ALK, CD30, белков цитотоксических гранул TIA-1, гранзимов В и/или перфоринов, в большинстве случаев эпителиального мембранного антигена EMA и вариабельная экспрессия Т-клеточных антигенов CD2, CD3, CD4, СD8, CD5, CD7 [7, 8].
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