Abstract
During viral infection, virus-specific follicular helper T cells provide important help to cognate B cells for their survival, consecutive proliferation and mutation and eventual differentiation into memory B cells and antibody-secreting plasma cells. Similar to Tfh cells generated in other conditions, the differentiation of virus-specific Tfh cells can also be characterized as a process involved multiple factors and stages, however, which also exhibits distinct features. Here, we mainly focus on the current understanding of Tfh fate commitment, functional maturation, lineage maintenance and memory transition and formation in the context of viral infection.
Highlights
Based on the biological process, viral infections can be divided into two groups: acute viral infection and chronic viral infection
This review primarily focuses on the current understanding of the fate commitment, functional maturation, and memory formation of Tfh cells during acute viral infection
Several groups confirmed that IL-6 and interleukin 21 (IL-21) signaling via the transcription factor STAT3 enhances the upregulated expression of Bcl6, which is the master regulator of Tfh differentiation
Summary
Based on the biological process, viral infections can be divided into two groups: acute viral infection and chronic viral infection. This review primarily focuses on the current understanding of the fate commitment, functional maturation, and memory formation of Tfh cells during acute viral infection.
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