Abstract
Long-term potentiation (LTP) at hippocampal mossy fiber synapses is distinct from most other forms of LTP. Mellor et al . found that the hyperpolarization-activated mixed cation current I h unexpectedly plays an important role. Calcium entry into the hippocampal granule cells during repetitive stimulation activates a calcium-calmodulin-sensitive adenylate cyclase. The subsequent rise in adenosine 3′,5′-monophosphate (cAMP) activates protein kinase A, which leads to increases in I h . The resulting depolarization causes an enhancement of mossy fiber synaptic transmission. J. Mellor, R. A. Nicoll, D. Schmitz, Mediation of hippocampal mossy fiber long-term potentiation by presynaptic I h channels. Science 295 , 143-147 (2002). [Abstract] [Full Text]
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