Abstract
Background The incidence of abdominal aortic aneurysms (AAAs) has increased in western societies and complications often lead to life threatening events. There is still controversy regarding the management of medium sized AAAs. Therefore, novel biomarkers, besides aneurysmal diameter, are needed to assess aortic wall integrity and risk of rupture. Elastin is the key protein for maintaining stability of the aortic and aneurysmal wall. Elastin degradation due to inflammation and metalloproteinases (MMPs) expression as well as de novo synthesis of immature elastin are considered key events in the development of AAAs. The aim of this study was to test a novel smallmolecular-weight elastin-specific MR probe for the in vivo assessment of arterial wall integrity in AAAs. Methods
Highlights
The incidence of abdominal aortic aneurysms (AAAs) has increased in western societies and complications often lead to life threatening events
The high signal provided by the elastin-specific MR probe allowed for imaging with high spatial resolution (100μm)
In vivo AAA area measurements were in good agreement (R2=0.95, p
Summary
The incidence of abdominal aortic aneurysms (AAAs) has increased in western societies and complications often lead to life threatening events. There is still controversy regarding the management of medium sized AAAs. novel biomarkers, besides aneurysmal diameter, are needed to assess aortic wall integrity and risk of rupture. Elastin is the key protein for maintaining stability of the aortic and aneurysmal wall. Elastin degradation due to inflammation and metalloproteinases (MMPs) expression as well as de novo synthesis of immature elastin are considered key events in the development of AAAs. The aim of this study was to test a novel smallmolecular-weight elastin-specific MR probe for the in vivo assessment of arterial wall integrity in AAAs
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