Abstract
In this study, we provided the detailed characterizations of our recent HRP-AuNPs/PEDOT:BSA/Pt biosensor, constructed through a simple fabrication procedure with improved stability and good sensitivity. Raman and Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy not only confirmed the synthesis of conductive PEDOT where BSA was the template for the polymerization, but also provided further insights into the stable immobilization of AuNP on the PEDOT:BSA film. Scanning electron microscopy revealed that the attachment of AuNPs were stable under a high salt environment. The current technology demonstrates a feasible procedure to form a functional AuNPs/PEDOT:BSA film that has potential applications in the fabrication of various biosensors and electric devices.
Highlights
While great progress has been made in modern medicine, the development of various innovative diagnostic sensors is becoming extremely important for precision medicine
Film from Pt electrodes during multiple measurements has become the major drawback for further applications. We have attributed this phenomenon to the synthesis of short PEDOT fragments due to the lack of templates and the heterogeneous natures of the hydrophobicity of PEDOT film against the slight hydrophilicity of platinum
We have demonstrated that the linearized proteins, such as bovine serum albumin (BSA), could be used as templates in the electrochemical synthesis of thermal stable PEDOT:BSA on the platinum (Pt) electrode [7]
Summary
While great progress has been made in modern medicine, the development of various innovative diagnostic sensors is becoming extremely important for precision medicine. In comparison with traditional chemical and biochemical approaches that are often complicated and tiresome, researchers are working on constructing diagnostic biosensors with more convenient operation protocols [1]. The peeling of PEDOT film from Pt electrodes during multiple measurements has become the major drawback for further applications. We have attributed this phenomenon to the synthesis of short PEDOT fragments due to the lack of templates and the heterogeneous natures of the hydrophobicity of PEDOT film against the slight hydrophilicity of platinum. We have demonstrated that the linearized proteins, such as bovine serum albumin (BSA), could be used as templates in the electrochemical synthesis of thermal stable PEDOT:BSA on the platinum (Pt) electrode [7]
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