Abstract
The diversity of the antibody repertoire is created atseveral levels. Mice and humans have approximately 100germ-line V genes and several (D and) J gene segments intheir heavy- and light-chain loci. A major amplificationof the germ-line repertoire occurs by V(D)J recombination during B-cell development. The repertoire is furtherdiversified by somatic hypermutation in mature B cellsthat have encountered antigen and T-cell help. Somatichypermutation is dependent on the formation of germinalcenters in the peripheral lymphoid organs...
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Schedule a callMore From: Cold Spring Harbor symposia on quantitative biology
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