Molecular Aspects of Myeloid Stem Cell Development

Abstract

Regulation of Myeloid Differentiation, Growth Arrest and Apoptosis.- Molecular Control of Development in Normal and Leukemic Myeloid Cells by Cytokines, Tumor Suppressor and Oncogenes.- Retinoic Acid Receptors in Hematopoiesis.- Role of c-myc in Myeloid Differentiation, Growth Arrest and Apoptosis.- Self Renewal and Differentiation in Primary Avian Hematopoietic Cells: An Alternative to Mammalian in Vitro Models?.- Receptors and Signal Transduction.- The Effect of C-raf Antisense Oligonucleotides on Growth Factor-Induced Proliferation of Hematopoietic Cells.- Protein Kinase C-?, an Important Signaling Molecule in the Platelet-Derived Growth Factor ? Receptor Pathway.- Novel Adapter Proteins that Link the Human GM-CSF Receptor to the Phosphatidylinositol 3-Kinase and Shc/Grb2/ras Signaling Pathways.- Myb: Proliferation and Maintenance of Stage Specific Genes.- Functional Analysis of the c-myb Proto-Oncogene.- Structure and Function of the Proteins Encoded by the myb Gene Family.- The c-Myb Negative Regulatory Domain.- Myeloid-Specific Transcription.- Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1.- A Role for STAT Family Transcription Factors in Myeloid Differentiation.- Regulation of C/EBP?/NF-M Activity by Kinase Oncogenes.- Function of PU.1 (Spi-1), C/EBP, and AML1 in Early Myelopoiesis: Regulation of Multiple Myeloid CFS Receptor Promoters.- Regulation of Immature Myeloid Cell Differentiation by PEBP2/CBF, MYB, C/EBP and ETS Family Members.- Hematopoietic Transcriptional Regulation by the Myeloid Zinc Finger Gene, MZF-1.- Coordinate Regulation of Neutrophil Secondary Granule Protein Gene Expression.- lnterleukin-5 Receptor ? Subunit Gene Regulation in Human Eosinophil Development: Identification of a Unique Cis-Element that acts lie an Enhacer in Regulating Activity of the IL-5R? Promoter.- Molecular Aspects of Myeloid Leukemia. I. Murine Studies.- Retroviral Insertional Mutagenesis in Murine Promonocytic Leukemias:c-myband Mm/1..- Molecular Analysis and Characterization of Two Myeloid Leukemia Inducing Murine Retroviruses.- Molecular Analysis of Evil, a Zinc Finger Oncogene Involved in Myeloid Leukemia.- Activation of Stat-related DNA-binding Factors by Erythropoietin and the Spleen Focus-Forming Virus.- The Neurofibromatosis Type 1 (NF1) Tumor Suppressor Gene and Myeloid Leukemia.- Molecular Aspects of Myeloid Leukemia. II. Human Studies.- Rearrangement of the AML1/CBFA2 Gene in Myeloid Leukemia with the 3 21 Translocation:Expression of Co-Existing Multiple Chimeric Genes with Similar Functions as Transcriptional Repressors, but with Opposite Tumorigenic Properties.- Transcriptional Regulation by the t(8 21 )Fusion Protein, AML-1/ETO.- The Mixed Lineage Leukemia (MLL) Protein Involved in 11 q23 Translocations Contains a Domain that Binds Cruciform DNA and Scaffold Attachment Region (SAR) DNA.- Pathogenetic Role of the PML/RAR? Fusion Protein in Acute Promyelocytic Leukemia.- Involvement of the TEL Gene in Hematologic Malignancy by Diverse Molecular Genetic Mechanisms.- Transforming Properties of the Leukemic Inv(16) Fusion Gene CBFB-MYH11..